Find out about CAR T-cell treatment for leukemia. Through our Transplant and Cellular Therapy Program, we offer CAR T-cell therapy to eligible children. It also involves reprogramming your child’s own cells to kill leukemia cells, so you don’t need a donor. It tends to have less side effects than a bone marrow transplant. CAR T-cell therapy is a revolutionary new leukemia treatment. This program helps set and improve the quality of stem cell transplants around the United States. Our doctors started a national program that reviews patient cases with transplant experts from 10 other institutions around the country. Read more about treating children with leukemia. We use medicines, support programs and innovative medical therapies to help your family manage and treat issues after a transplant. These long-term effects can increase the risk for infections and other complications. Bone marrow transplants affect the immune system for months - even years. Expertise in managing transplant complications.With this information, your child’s transplant team can readjust the treatment plan to make the process safer. These risk assessments involve tests that can find issues that may increase your child’s risk for transplant complications. Before a pediatric stem cell transplant, your child undergoes a detailed risk assessment. Our combined expertise allows us to diagnose and treat common, rare and complex leukemias and other diseases. News & World Report named Nemours Children’s Hospital, Delaware one of the “Best Hospitals”). We also rank among the very best in the country for both pediatric orthopedics (bone treatment) and cancer care ( U.S. Only hospitals with the highest-quality bone marrow transplant care and best outcomes have earned this accreditation. Our Transplant and Cellular Therapy Program is accredited by the Foundation for Accreditation of Cellular Therapies (FACT). Many insurance providers also recognize us as a Center of Excellence. The National Marrow Donor Program (NMDP) has recognized Nemours Children’s as an affiliated center for matched unrelated donor transplants. Learn more about treating childhood leukemia. Leukemia is cancer of the white blood cells, which starts in the bone marrow.ĭoctors treat different types of childhood leukemia with allogenic bone marrow transplants, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Similar to an autologous stem cell transplant transplant, patients are typically treated with chemotherapy or radiation or immunotherapy to remove unhealthy cells and then receive a stem cell infusion, except in an allogeneic stem cell transplant, doctors get healthy stem cells from a donor’s bone marrow or blood.ĭoctors use allogeneicstem cell transplants to treat leukemia, the most common form of childhood cancer. When a parent, sibling or unrelated person donates genetically matched stem cells, it’s called an allogeneic stem cell transplant. Recently autologous bone marrow transplants have been used in clinical trials as the vehicle for gene therapy. The primary goal of an autologous bone marrow transplant is to “rescue” a child from the effects of high doses of chemotherapy. Doctors typically use peripheral blood stem cells that are collected prior to the transplant and then frozen for later use.:Īfter intensive treatment such as high-dose chemotherapy, doctors reinfuse the stem cells back into the child’s blood. If kids use their own stem cells, it’s called an autologous stem cell transplant (or autologous bone marrow rescue). There are two main types of pediatric stem cell transplants: Autologous bone marrow transplant
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